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Inhibitors of the CD47–SIRPα interaction improve antitumor antibody responses by enhancing antibody-dependent cellular phagocytosis (ADCP) in xenograft models. Therefore, targeting CD47 may be a novel strategy for cancer immunotherapy, and a variety of anti-CD47 antibodies have appeared, such as humanized 5F9 antibody, B6H12 antibody, ZF1 antibody, and so on. This review mainly describes the research history of CD47-SIRPα and focuses on macrophage-mediated CD47-SIRPα immunotherapy of tumors. Tuesday, June 23, 2020 NIH investigators hope CD47 study leads to broad-spectrum infectious diseases immunotherapy Colorized scanning electron micrograph of a cell (purple) infected with SARS-COV-2 virus particles (yellow), isolated from a patient sample. Image captured at the NIAID Integrated Research Facility (IRF) in Fort Detrick, Maryland. Targeting CD47 represents a novel immunotherapeutic strategy and holds great potential to improve the antitumor immune responses mediated by the macrophages. This approach has shown positive results for the treatment of B-cell malignancies, acute leukemia, ovarian and colorectal cancer.

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These results suggest that anti-CD47 mAbs are applicable for MM treatment, and further studies are warranted to examine the effect of anti-CD47 mAbs as a novel checkpoint immunotherapy to target MM in vivo and in patients. NIH investigators hope CD47 study leads to infectious diseases immunotherapy. by NIH/National Institute of Allergy and Infectious Diseases 2018-12-10 · Michaels, A. D. et al. CD47 blockade as an adjuvant immunotherapy for resectable pancreatic cancer. Clin.

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Ther. offers a valuable resource for researchers in the cancer immunotherapy field, checkpoint regulation and develop safer and more effective immunotherapies. Cancer Immunotherapy (CIMT) Annual Meeting, 10-12 maj, 2021 Alex of Research på Immunicum, håller ett anförande på temat “CD47 and  Cancer Immunotherapy (CIMT) Annual Meeting, 10-12 maj, 2021 på temat“CD47 and phosphatidylserine contribute to the interaction  Cancer immunology, immunotherapy : CII - 2014-01-01 CD47-deficient mice have decreased production of intestinal IgA following oral immunization but a  AbbVie Strikes Deal for I-Mab Drug With a Potential Edge in CD47 immunotherapy developer and its lead CD47 inhibitor, magrolimab." Cancer Immunotherapy (CIMT) Annual Meeting, May 10 – 12, 2021.

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Recently, CD47 blockade by Hu5F9-G4 has shown promise combined with Rituximab in non-Hodgkin’s lymphoma.

x CD3 therapeutic bispecific antibody for bladder carcinoma immunotherapy. LRRC15 x CD3 Bispecific T Cell Engager · QL Tumor Targeted CD47 Blocker. händelser, inklusive förlust av "inte äta mig" signaler (som CD31 och CD47 3, situation concerning the anti-CTLA-4 antibody-based cancer immunotherapy.
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CD47 is an antiphagocytic ligand broadly expressed on normal and malignant tissues that delivers an inhibitory signal through the receptor signal regulatory protein alpha (SIRPα). Inhibitors of the CD47–SIRPα interaction improve antitumor antibody responses by enhancing antibody-dependent cellular phagocytosis (ADCP) in xenograft models. Therefore, targeting CD47 may be a novel strategy for cancer immunotherapy, and a variety of anti-CD47 antibodies have appeared, such as humanized 5F9 antibody, B6H12 antibody, ZF1 antibody, and so on. This review mainly describes the research history of CD47-SIRPα and focuses on macrophage-mediated CD47-SIRPα immunotherapy of tumors. Tuesday, June 23, 2020 NIH investigators hope CD47 study leads to broad-spectrum infectious diseases immunotherapy Colorized scanning electron micrograph of a cell (purple) infected with SARS-COV-2 virus particles (yellow), isolated from a patient sample.

anti-CD47 immunotherapy (Chao et al., 2011; Horrigan and Reproducibility Project: Cancer Biology, 2017; Willingham et al., 2012). Together, those findings raise the possibility that gut microbiota influence anti-CD47 immunotherapy through changing the local microenvironment, challenging the current gut immunity-initiated model.
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Aug 28, 2018 Tumor immunotherapy targeting CD47/SIRPα axis has been one hotspot in cancer therapy. Here, we summarize the preclinical evidence and  Apr 18, 2018 The CD47 immune checkpoint represents a potentially effective and widely applicable target for cancer immunotherapy, and therefore a  Sep 19, 2017 Inhibitors of the CD47–SIRPα interaction improve antitumor antibody responses The success of combination immunotherapy involving CD47  Sep 22, 2020 Scholars have clarified the mechanism of action of CD47-SIRPα, and macrophage-mediated tumor immunotherapy has gained increasing  Sep 4, 2020 The cancer protein CD47 is a hot target for drug developers, but it's not immunotherapy developer and its lead CD47 inhibitor, magrolimab. GD2-based immunotherapy has become standard of care for neuroblastoma patients but has not yet mediated clinical benefit for those with osteosarcoma. New immunotherapy possible for canine cancer blocking a cell surface protein called CD47 might be a potent treatment for a wide variety of human cancers. Nov 13, 2020 ALX148 showcased favorable safety and elicited objective responses when combined with trastuzumab, pembrolizumab, and multiagent  Apr 14, 2020 Therapeutic CD47 blockade enhances T cell responses and Evaluation of Anti- CD47 Immunotherapy against Established HIV-1 Infection in  Mar 6, 2020 revealing that gut bacteria can penetrate tumor cells and boost the effectiveness of an experimental immunotherapy that targets the CD47  Keywords. CD47, SIRPα, immunotherapy, tumor microenvironment, pediatric cancer, innate immune system, checkpoint inhibitor, phagocytosis  Mar 30, 2020 antibodies to block CD47, a “don't eat me” signal on cancer cells, presently in development;; and immunotherapy drugs that block the PD-1  CD47, Do not eat me signal, Macrophage, Phagocytosis, Immunotherapy.